Publications

UIC Publications

Yao, Y.; Kong, C.; Yin, L.; Jain, A. D.; Ratia, K.; Thatcher, G. R.; Moore, T. W.; Driver, T. G.; Miller, L. W. Time-gated detection of cystathionine γ-lyase activity and inhibition with a selective, luminogenic hydrogen sulfide sensor.  Chemistry – A European Journal 2017, 23, 752. doi: 10.1002/chem.201604786. PMID: 27734530.

Speltz, T. E.; Fanning, S. W.; Mayne, C. G.; Fowler, C.; Tajkhorshid, E.; Greene, G. L.; Moore, T. W.* Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction. Angewandte Chemie International Edition 2016, 55, 4252-4255. doi: 10.1002/anie.201510557 and 10.1002/ange.201510557. PMID: 26928945.

Xiong, R.; Patel, H.; Gutgesell, L.; Zhao, J.; Delgado-Rivera, L.; Pham, T.; Zhao, H.; Carlson, K. E.; Martin, T. F.; Katzenellenbogen, J. A.; Moore, T. W.; Tonetti, D.; Thatcher, G. R. J. Selective human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer. Journal of Medicinal Chemistry 2016, 59, 219-237. doi: 10.1021/acs.jmedchem.5b01276.

Jain, A. D.; Potteti, H.; Richardson, B. G.; Kingsley, L.; Luciano, J. P.; Ryuzoji, A. F.; Lee, H.; Krunic, A.; Mesecar, A. D.; Reddy, S. P.; Moore, T. W.* Probing the Structural Requirements of Non-electrophilic Naphthalene-Based Nrf2 Activators. European Journal of Medicinal Chemistry 2015,103, 252-268. doi:10.1016/j.ejmech.2015.08.049.

^ = equal contribution

PowerPoint Presentation

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Richardson, B. G.; Jain, A. D.; Speltz, T. E.; Moore, T. W.* Non-electrophilic modulators of the canonical Keap1/Nrf2 pathwayBioorganic and Medicinal Chemistry Letters 2015, 25, 2261-2268. doi: 10.1016/j.bmcl.2015.04.019.

     

 Publications from work before UIC

Liver S9 Fraction-Derived Metabolites of Curcumin Analogue UBS109

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Moore, T. W.; Zhu, S.; Randolph, R.; Shoji, M.; Snyder, J. P. Liver S9 Fraction-Derived Metabolites of Curcumin Analog UBS109. ACS Medicinal Chemistry Letters 2014. doi: 10.1021/ml4002453.

 

 

 

Synthesis and Metabolic Studies of Host-Directed Inhibitors for Antiviral Therapy

ml-2013-00166b_0013Moore, T. W.; Sana, K.; Yan, D.; Krumm, S. A.; Thepchatri, P.; Snyder, J. P.; Marengo, J.; Arrendale, R. F.; Prussia, A. J.; Natchus, M. G.; Liotta, D. C.; Plemper, R. K.; Sun, A.  Synthesis and Metabolic Studies of Host-Directed Inhibitors for Anti-Viral Therapy. ACS Medicinal Chemistry Letters 2013, 4, 762-767. doi: 10.1021/ml400166b. PMID: 23956816. PMCID: PMC3743129.

 

 Monocarbonyl Curcumin Analogs: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate Anti-Cancer Properties

jm-2013-002692_0013Brown, A.; Shi, Q.; Moore, T. W.; Yoon, Y.; Prussia, A.; Maddox, C.; Liotta, D. C.; Shim, H.; Snyder, J. P. Monocarbonyl Curcumin Analogs: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate Anti-Cancer Properties.  Journal of Medicinal Chemistry 2013, 56, 3456-3466. doi: 10.1021/jm4002692. PMID: 23550937. 

 

 Asymmetric Synthesis of Host-Directed Inhibitors of Myxoviruses

newMoore, T. W.; Sana, K.; Yan, D.; Thepchatri, P.; Ndungu, J. M.; Saindane, M. T.; Natchus, M. G.; Liotta, D. C.; Plemper, R. K.; Snyder, J. P.; Sun, A. Asymmetric Synthesis of Host-Directed Inhibitors of Myxoviruses. Beilstein Journal of Organic Chemistry2013,9, 197–203. doi: 10.3762/bjoc.9.23. PMID: 23400228. PMCID: PMC3566758. 

 

 Novel curcumin analogue UBS109 potently stimulates osteoblastogenesis and suppresses osteoclastogenesis in vitro

 GAYamaguchi, M.; Moore, T. W.; Sun, A.; Snyder, J. P.; Shoji, M. Novel curcumin analogue UBS109 potently stimulates osteoblastogenesis and suppresses osteoclastogenesis in vitro. Integrative Biology2012, 4, 905-913. doi: 10.1039/c2ib20045g. PMID: 22751853. 

 

 

Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts

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Zhu, S.; Moore, T. W.; Lin, X.; Morii, N.; Mancini, A.; Howard, R. B.; Culver, D.; Arrendale, R. F.; Reddy, G. P.; Evers, T. J.; Zhang, H.; Sica, G.; Chen, Z. G.; Sun, A.; Fu, H.; Khuri, F. R.; Shin, D. M.; Snyder, J. P.; Shoji, M. Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts. Integrative Biology 2012, 4, 633-640. doi: 10.1039/c2ib20007d.

 Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties

NIHMS350845.htmlOlivera, A.; Moore, T. W.; Sun, A.; Hu, F.; Liotta, D. C.; Snyder, J. P.; Shim, H.; Marcus, A. I.; Miller, A. H.; Pace, T. W .W. Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. International Immunopharmacology 2012, 12, 368-377. doi: 10.1016/j.intimp.2011.12.009. PMID: 22532032. PMCID: PMC3734847 

 

 

 

Discovering Small Molecule Estrogen Receptor α/Coactivator Binding Inhibitors: High-Throughput Screening, Ligand Development, and Models for Enhanced Potency

nihms316434f6Sun, A.; Moore, T. W.; Gunther, J. R.; Kim, M. S.; Rhoden, E.; Du, Y.; Fu, H.; Snyder, J. P.; Katzenellenbogen, J. A.  Discovering Small Molecule Estrogen Receptor α/Coactivator Binding Inhibitors: High-Throughput Screening, Ligand Development, and Models for Enhanced Potency. ChemMedChem 2011, 6, 654-666. doi: 10.1002/cmdc.201000507. PMID: 21365764. PMCID: PMC3177402. 

 

Probing the Topological Tolerance of Multimeric Protein Interactions: Evaluation of anEstrogen/Synthetic Ligand for FK506 Binding Protein Conjugate

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  Moore, T. W.; Gunther, J. R.; Katzenellenbogen, J. A. Probing the Topological Tolerance of Multimeric Protein Interactions: Evaluation of an Estrogen/Synthetic Ligand for FK506 Binding Protein Conjugate. Bioconjugate Chemistry 2010, 21, 1880-1889. doi: 10.1021/bc100266v. PMID: 20919698. PMCID: PMC2967433.

 

 

 

 

Not picking pockets: Nuclear Receptor Alternate-site Modulators (NRAMs)

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Moore, T. W.; Mayne, C. G.; Katzenellenbogen, J. A. Not picking pockets: Nuclear Receptor Alternate-site Modulators (NRAMs). Molecular Endocrinology2010, 24, 683-695. doi: 10.1210/me.2009-0362. PMID: 19933380. PMCID: PMC2852352. 

 

 

 

 

 

Inhibitors of nuclear hormone receptor/coactivator interactions

 

Moore, T. W.; Katzenellenbogen, J. A. Inhibitors of nuclear hormone receptor/coactivator interactions. Annual Reports in Medicinal Chemistry2009, 44, 443-457. doi:10.1016/S0065-7743(09)04421-2. 

 

 A set of time-resolved fluorescence resonance energy transfer assays for the discovery of inhibitors of estrogen receptor-coactivator binding

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Gunther, J. R.; Du, Y.; Rhoden, E.; Lewis, I.; Revennaugh, B.; Moore, T. W.; Kim, S. H.; Dingledine, R.; Fu, H.; Katzenellenbogen, J. A. A set of time-resolved fluorescence resonance energy transfer assays for the discovery of inhibitors of estrogen receptor-coactivator binding. Journal of Biomolecular Screening 2009, 14, 181-193. doi: 10.1177/1087057108329349. PMID: 19196699. PMCID: PMC2731238. 

 

Amphipathic benzenes are designed inhibitors of the estrogen receptor α/steroid receptor coactivator interaction

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 Gunther, J. R.; Moore, T. W.; Collins, M. L.; Katzenellenbogen, J. A. Amphipathic benzenes are designed inhibitors of the estrogen receptor α/steroid receptor coactivator interaction. ACS Chemical Biology2008, 3, 282-286. doi: 10.1021/cb800056r. PMID: 18484708. PMCID: PMC2427189. 

 

Layered compounds incorporating 9,9′-spirobifluorene: Hydrogen-bonded and metal-organic networks derived from 9,9′-spirobifluorene-2,2′,7,7′-tetracarboxylic acid

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Clews, P. K.; Douthwaite, R. E.; Kariuki, B. M.; Moore, T.; Taboada, M. Layered compounds incorporating 9,9′-spirobifluorene: Hydrogen-bonded and metal-organic networks derived from 9,9′-spirobifluorene-2,2′,7,7′-tetracarboxylic acid. Crystal Growth and Design2006, 6, 1991-1994. doi:10.1021/cg060007d. 

 

 

Electronic properties of the trimethylenemethaneiron tricarbonyl group

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Moore, T.; Kiely, C.; Reeves, P. C. Electronic properties of the trimethylenemethaneiron tricarbonyl group. Journal of Organometallic Chemistry2001, 620, 308-312. doi:10.1016/S0022-328X(00)00812-3.